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PhD thesis offers by research teams (Tours campus) of the Doctoral School SSBCV for the year 2018-2019


from March 13, 2018 to April 23, 2018

The Doctoral School "Health, Biological Sciences and Life Chemistry" (ED 549, SSBCV), joint between Tours and Orléans, includes about 320 researchers and 280 PhD students. The Doctoral School will prosose to fund the PhD program (3 years, starting on September 2018) of several students on different topics, listed bellow.

The students interested in these PhD programs should contact the thesis supervisor listed on each abstract. For each project, the PhD supervisor will select 3 students that will be auditioned by the Doctoral Council on May and June 2017. A laureate will be then selected for each topic.
Please note that not all proposed PhD programs will receive a three-year PhD grant. You should contact the PhD supervisor directly to get information.

The list bellow corresponds to PhD proposals within the four thematic sectors A, B, D, E of the DS which are eligible for a PhD funding by the University of Tours, by Région Centre Val de Loire or co-funded with Région Centre VdL.
Not all offers will benefit from such a funding. Those already benefiting from a financial support are labelled (F). This list will be updated as and when required.

If you are interested to apply or if you need additional information, you must contact the PhD supervisor, the email of which is indicated in the downloadable abstract.

Please note that the deadline to apply to PhD thesis labelled with a (F) is april 23th, 2018. Candidate application forms (3 maximum) are sent by the PhD supervisor. The next recruitment campaign will occur next june i.e when all PhD fundings will be attributed.

Curriculum A : Human and animal physiopathology

  • Eco-extraction of lipids of dermatological interest (F)
    Dir. de thèse : Leslie Boudesocque-Delaye
    Download the summary
  • Elucidation and engineering of the biosynthesis of Apocynaceae-alkaloids of pharmaceutical interest (F)
    Dir. de thèse : Marc Clastre
    Download the summary
  • Impact of introduction in selection of new criteria of feed efficiency on sustainability of broiler production
    Dir. de thèse : Sandrine Grasteau/Elisabeth Le Bihan-Duval
    Download the summary
  • Impact of overexpression of proteases, cysteine cathepsins, on the integrity of epithelial barriers in COPD (Chronic Obstructive Pulmonary Disease)
    Dir. de thèse : Gilles Lalmanach
    Download the summary
  • Effects of polyunsaturated fatty acids on calcium-mediated regulation of the epithelial-mesenchymal transition in prostate cancer (F)
    Dir. de thèse : Karine Mahéo/Gaëlle Fromont
    Download the summary
  • Histone Deacetylases (HDAC) in colon cancer: roles in cancer cells invasiveness and metastatic progression
    Dir. de thèse : Ouaïssi Mehdi/Sébastien Roger
    Download the summary
  • Identification of novel genes involved in intellectual disability by functional genomic
    Dir. de thèse : Annick Toutain
    Download the summary
  • Regulation of the ether-lipids sensitive SK3 channel by cholesterol
    Dir. de thèse : Christophe Vandier/Philippe Franck
    Download the summary

Curriculum B : Infectiology, Immunology, Symbiosis

  • Étude du rôle du récepteur purinergique P2X4 dans les cellules dendritiques et la réponse inflammatoire associée au processus d’ischémie-reperfusion myocardique.
    Dir. de thèse : Denis Angoulvant
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  • Immunothérapie de la toxoplasmose par des conjugués anticorps-médicament (ADC)
    Dir. de thèse : Françoise Debierre-Grockiego
    Download the summary
  • Impact of the SOS response on the conjugative transfer and maintenance of integrative conjugative elements disseminating antimicrobial resistance
    Dir. de thèse : Benoît Doublet/Axel Cloeckaert
    Download the summary
  • Evolution of recently domesticated viruses in Campopleginae parasitoid wasps
    Dir. de thèse : Elisabeth Huguet
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  • Regulatory RNAs in the pathogen Streptococcus agalactiae (F)
    Dir. de thèse : Marie-Frédérique Lartigue
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  • Interaction des virus de l’hépatite C et E avec les composants des lipoprotéines : utilisation potentielle comme cible thérapeutique antivirale.
    Dir. de thèse : Jean-Christophe Meunier
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  • Deciphering the innate immune evasion strategies employed by highly pathogenic avian influenza viruses and their phylogenetic precursors in chicken endothelial cells
    Dir. de thèse : Pascale Quéré
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  • Characterization of virulence factors and their cellular targets in the avian model of Eimeria tenella infection   (F)
    Dir. de thèse : Anne Silvestre
    Download the summary
  • Development of an innovative host-directed anti-influenza therapy - in vitro and in vivo approaches (F)
    Dir. de thèse : Mustapha Si-Tahar
    Download the summary
  • The Rck invasin, a new invasion factor of Salmonella : target cells and in vivo expression
    Dir. de thèse : Isabelle Virlogeux-Payant
    Download the summary

Curriculum D : Biology of reproduction, Cognitive sciences and development, Ecology

  • Characterizing circuits underlying the hippocampal control of stress response (F)
    Dir. de thèse : Vincent Camus
    Download the summary
  • Role of olfactory Gαi2 signal transduction mechanisms mediating reproductive and sociosexual behaviors (F)
    Dir. Pablo Chamero-Benito
    Download the summary
  • Control of the conformational dynamics of the follicle-stimulating hormone receptor with intrabodies and functional consequences
    Dir. de thèse : Pascale Crépieux/Gilles Bruneau
    Download the summary
  • Behavioural and genetic consequences of inbreeding in the invasive hornet Vespa velutina nigrithorax in Europe
    Dir. de thèse : Eric Darrouzet
    Download the summary
  • New paradigms for the induction of ovulation - application to the equine species.
    Dir. de thèse : Anne Duittoz/Massimiliano Beltramo
    Downloard the summary
  • Effects and mechanism of action of bisphenol S on granulosa cell functions (F)
    Dir. de thèse : Sébastien Elis
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  • Effet de perturbateurs endocriniens potentiels sur les fonctions mâles d’insectes parasitoïdes
    Dir. de thèse : Charlotte Lécureuil
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  • Role of the mu opioid and oxytocin receptors and their interaction in the control of social behavior
    Dir. de thèse : Julie Le Merrer
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  • Interactions between the neurogenic niche and the vascular niche in the adult hypothalamus
    Dir. de thèse : Martine Migaud
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  • The effect of the presence or absence of maternal care on the neurobiological, emotional and cognitive development of lambs
    Dir. de thèse : Raymond Nowak/ Cathy Dwyer
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  • Language capacities of low functioning French-speaking children with autism
    Dir. de thèse : Philippe Prévost
    Download the summary

Curriculum E : Technology for health, Therapeutic targetting, Imaging

  • Targeted nanomedicines to overcome the chemoresistance of triple negative breast cancers (F)
    Dir. de thèse : Emilie Allard-Vannier
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  • Multiscale MRI atlas of the human brainstem
    Dir. de thèse : Christophe Destrieux
    Download the summary
  • Neurophysiological consequences of acoustically-mediated blood-brain barrier opening   (F)
    Dir. de thèse : Jean-Michel Escoffre
    Download the summary
  • Functional analysis of STAT proteins in quiescence and chemoresistance of leukemic cells: regulation by the microenvironment
    Dir. de thèse : Fabrice Gouilleux
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  • Analysis of FcRn expression and its targeting for a new anti-cancer therapy
    Dir. de thèse : Valérie Gouilleux-Gruart
    Download the summary
  • Towards Antibody-Drug Conjugates with Controlled Drug Delivery in the Tumor Microenvironment for Cancer Therapy  (F)
    Dir. de thèse: Nicolas Joubert
    Download the summary
  • Increase of anti-EGFR monoclonal antibodies efficacy by association with curcumin or curcumin analogs in metastatic colorectal cancer ?
    Dir. de thèse : Thierry Lecomte/William Raoul
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  • Metabolic network during neurodevelopmental windows in rodent models
    Dir. de thèse : Sylvie Mavel
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  • Aerosolized nanovectored interfering olignucleotides for the treatment of lung fibrosis in mouse models
    Dir. de thèse Laurent Plantier
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  • Intraoperative characterization of brain tumors and peritumoral infiltration area by ultrasound elastography and micro-vascular imaging of blood flow
    Dir. de thèse : Jean-Pierre Remeniéras
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