UE 9.3 : Mucosal Immunity

  • Objectives 
Study of the mucosa-associated immune system and anti-infectious mucosal immunity.
  • Methodological and technical skills acquired
This module will bring theoretical knowledge on peculiarities of the mucosa-associated immune system in the context of viral, parasitic or bacterial infections or of inflammations. Interactions between the intestinal microbiota with the host and its consequences on the maturation of the immune system and the preservation of intestinal homeostasis will also be studied.
  • Program and Content of the Module
Theoretical courses : 20 h
• Characteristics of the mucosal intestinal barrier.
• Characteristics of the normal and pathologic respiratory mucosa
• Innate lymphocytes of the mucosa
• Physiopathology of intestine inflammatory diseases
• Lymphoid tissues of the intestinal mucosa
• Antigen processing and induction of the specific immune response
• Flora and maturation of the immune system
• Role of NLRs and TLRs receptors in the intestine
• Lymphatic cannulation animal models
• Helicobacter pylori and gastric mucosa cancers
• Anti-parasitic immunity (protozoan)
• Pulmonary anti-viral immunity (Influenza)
• Control of infections by IgA (HIV)
• Anti-bacterial immunity (Salmonella)
• Anti-bacterial immunity (Mycobacteria)

Tutorials : 10 h